Abstract
Immunity and mitochondria are interlinked with each other. An important feature of mitochondria is it can regulate activation, differentiation, and survival of immune cells. In addition, it can also release signals such as mitochondrial DNA (mtDNA) and mitochondrial ROS (mtROS) to regulate transcription of immune cells. Risk factors for mitochondrial dysfunction and by proxy the immune system include antibiotics, pesticides and covid and spike protein. mitochondria have emerged as signaling organelles that contribute critical decisions about cell proliferation, death, and differentiation. Mitochondria not only sustain immune cell phenotypes but also are necessary for establishing immune cell phenotype and their function. Mitochondria can rapidly switch from primarily being catabolic organelles generating ATP to anabolic organelles that generate both ATP and building blocks for macromolecule synthesis. This enables them to fulfill appropriate metabolic demands of different immune cells. Mitochondria have multiple mechanisms that allow them to activate signaling pathways in the cytosol including altering in AMP/ATP ratio, the release of ROS and TCA cycle metabolites, as well as the localization of immune regulatory proteins on the outer mitochondrial membrane. Mitochondria are hubs in cellular signaling and produce ROS that drive production of inflammatory cytokines and play a role in removing bacteria.
Front. Immunol., 11 July 2018 Sec. Molecular Innate Immunity. Volume 9 – 2018 | https://doi.org/10.3389/fimmu.2018.01605
Vaccines break the immune system.
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