Reference: Ghielmetti M, Schaufelberger HD, Mieli-Vergani G, Cerny A, Dayer E, Vergani D, Terziroli Beretta-Piccoli B. Acute autoimmune-like hepatitis with atypical anti-mitochondrial antibody after mRNA COVID-19 vaccination: A novel clinical entity? J Autoimmun. 2021 Sep;123:102706. doi: 10.1016/j.jaut.2021.102706. Epub 2021 Jul 15. PMID: 34293683; PMCID: PMC8279947.

Abstract

Autoimmune phenomena and clinically apparent autoimmune diseases, including autoimmune hepatitis, are increasingly been reported not only after natural infection with the SARS-CoV-2 virus, but also after vaccination against it. We report the case of a 63-year old man without a history of autoimmunity or SARS-CoV-2 natural infection who experienced acute severe autoimmune-like hepatitis seven days after the first dose of the mRNA-1273 SARS-CoV-2 vaccine. Liver histology showed inflammatory portal infiltrate with interface hepatitis, lobular and centrilobular inflammation with centrilobular necrosis, in absence of fibrosis and steatosis. Serum immunoglobulin G was slightly elevated. Autoimmune liver serology showed an indirect immuno fluorescence pattern on triple rodent tissue compatible with anti-mitochondrial antibody (AMA), but, unexpectedly, this pattern was not mirrored by positivity for primary biliary cholangitis (PBC)-specific molecular tests, indicating that this antibody is different from classical AMA. Anti-nuclear antibody (ANA) was also positive with a rim-like indirect immuno fluorescence pattern on liver and HEp2 cell substrates, similar to PBC-specific ANA; however, anti-gp210 and a large panel of molecular-based assays for nuclear antigens were negative, suggesting a unique ANA in our patient. He carries the HLA DRB1*11:01 allele, which is protective against PBC. Response to prednisone treatment was satisfactory. The clinical significance of these novel specificities needs to be further evaluated in this emerging condition.

Keywords: SARS-Cov-2, mRNA vaccine, Autoimmune-like hepatitis, Atypical anti-mitochondrial antibody

Jyrkkanen Comment: The mRNA-1273 SARS-CoV-2 vaccine vaccination appears to have induced anti-mitochondrial antibody AMA and anti-nuclear antibody ANA, suggesting the primary support genetic reservoirs of the host had turned antigenic and become autoimmune targets for attack by the hosts immune system. I suspect it is from spike protein. This autoimmune reaction would lead to the destruction of the source of ATP+NAD production and immune system integrity and would lead to and increased risk of cancer, heart disease and other medical conditions.

CONSEQUENCES OF LOSS OF A VACCINATED POPULATIONS’ IMMUNE INTEGRITY MIGHT BE BE AN INCREASE IN RARE DISEASES EX: MONKEY POX IN ISRAEL

Twitter Censors Pfizer-Injured Israeli COVID Vaccine Director

Prof. Shmuel Shapira MD MPH (Col.), who served as Director of the Israel Institute for Biological Research between 2013 and 2021, suggested that the monkeypox outbreak was connected to mRNA vaccines.

Aug 3, 2022

Professor Shmuel Shapira, M.D., MPH, served as the Director General of the Israel Institute for Biological Research (IIBR) between 2013 and 2021, where he led Israel’s effort to develop a coronavirus vaccine.

Prof. Shapira is also the founder and head of the Department of Military Medicine of the Hebrew University Faculty of Medicine and IDF Medical Corps. He is a Senior Research Fellow at the International Institute for Counter-Terrorism (ICT) at Reichman University in Israel.

Shapira previously served as Deputy Director General of the Hadassah Medical Organization and as the Director of the Hebrew University Hadassah School of Public Health. He is a Full Colonel (Res.) in the Israel Defense Forces (IDF) and served as the IDF Head of Trauma Branch.

He has published more than 110 peer-reviewed scientific articles and is the editor of Essentials of Terror Medicine, Best Practice for Medical Management of Terror Incidents, and Medical Response to Terror Threats.

Last week, Twitter censored Prof. Shapira—who was “physically injured” after his third Pfizer vaccine—and forced him to remove a post which said: “Monkey pox cases were rare for years. During the last years a single case was documented in Israel. It is well established the mRNA vaccines affect the natural immune system. A monkey pox outbreak following massive covid vaccination: *Is not a coincidence.”

Dr. Eli David @DrEliDavid

Prof. @shmuelcshapira, head of Israel Biological Institute (the most senior medical-scientific position in Israel) posted on the connection between monkeypox and you-know-what. Twitter locked his account and forced him to delete it. They know more about biology than him 🤡

2:15 PM ∙ Jul 28, 2022